A Drosophila pasha Mutant Distinguishes the Canonical MicroRNA and Mirtron Pathways

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A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.

Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature approximately 22 nucleotide regulatory RNAs. We generated a null allele of Drosophila pasha, which encodes a double-stranded RNA-binding protein partner of the RNase III enzyme Drosha. Analysis of this mutant yielded stringent evidence that Pasha is essenti...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 2009

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.01524-08